Unsupervised hierarchical clustering integrated BMI, activity, comorbidities, HAQ and TNF pathway genetics to identify three RA subgroups with differing TNFi response rates, including a better-prognosis cluster with 73.5% response.
Researchers applied unsupervised hierarchical clustering to 294 rheumatoid arthritis patients to integrate clinical, demographic, and genetic data related to Tumor Necrosis Factor inhibitor response. By publication date 2026-08-17 they reported distinct responder characteristics and identified three subgroups ranging from 73.5% response to 82.9% therapeutic failure.
- Impact 30%
- 63
- Evidence 25%
- 95
- Scale 20%
- 35
- Confidence 15%
- 87
- Recency 10%
- 90
Updated Aug 18, 2026 · TRV-2026-0822
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