+ HEALTH Aims Intramuscular fat (IMF) is increasingly recognized as a marker of ectopic adiposity and adverse cardiome…+ HEALTH Periapical lesions are challenging to detect on intraoral radiographs because of anatomical superimposition a…± HEALTH Ultrasound imaging is an indispensable diagnostic tool, yet its profound reliance on operator expertise inher…+ HEALTH Objectives We adapted the individualized polysocial risk score (iPsRS), a machine learning model originally d…± HEALTH Melioidosis is a life-threatening infectious disease caused by Burkholderia pseudomallei ( Bp ). Rapid diagno…+ HEALTH Classification is a core machine learning task, and ensemble voting methods are widely used to improve predic…+ CLIMATE Microplastic (MP) pollution poses escalating environmental risks, demanding efficient and reproducible tools…± HEALTH Medicinal chemistry sits at the center of modern drug discovery, yet translating molecular designs into appro…
TruaceTracing the truth around AIWednesday, August 26, 2026
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TRV-2026-0822Certified recordPeer-reviewed

Clustering of rheumatoid arthritis patients: an unsupervised machine learning approach for characterizing the TNFi response

This study aimed to identifydistinct profiles of response to Tumor Necrosis Factor inhibitors (TNFi) in rheumatoid arthritis (RA) patients using unsupervised machine learning to integrate clinical, demographic, and genetic data. A cohort of 294 RA patients was analyzed using hierarchical clustering techniques. Data collected included body mass index (BMI), adherence to physical activity, prevalence of comorbidities, seropositivity, Health Assessment Questionnaire (HAQ) scores, and genetic polymorphisms in TNF pa…

Health · G Space — documented gain · certified 2026-08-18 · v1 · article view · machine-readable

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Unsupervised hierarchical clustering integrated BMI, activity, comorbidities, HAQ and TNF pathway genetics to identify three RA subgroups with differing TNFi response rates, including a better-prognosis cluster with 73.5% response.

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Truvace Impact Record TRV-2026-0822, v1: “Clustering of rheumatoid arthritis patients: an unsupervised machine learning approach for characterizing the TNFi response.” Truvace, 2026-08-18. /record/TRV-2026-0822 (accessed at citation time). sha256 9e34e92a15810097…

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