A logistic regression model combining grayscale ultrasound, contrast-enhanced ultrasound, and serum TPO-Ab improved differentiation of benign versus malignant thyroid nodules in Hashimoto's thyroiditis, reaching cross-validated AUC 0.849 with 77.3% sensitivity and 77.8% specificity.
Researchers retrospectively analyzed 600 patients with Hashimoto's thyroiditis and 650 pathology-confirmed thyroid nodules to test whether combining grayscale ultrasound, contrast-enhanced ultrasound, and serum anti-thyroid peroxidase antibody improves malignancy differentiation. They built a logistic regression model on patients with complete data and performed stratified 5-fold cross-validation, also comparing six machine learning classifiers.
- Impact 30%
- 63
- Evidence 25%
- 95
- Scale 20%
- 35
- Confidence 15%
- 87
- Recency 10%
- 94
Updated Sep 9, 2026 · TRV-2026-1027
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