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TRV-2026-1027Certified recordPeer-reviewed

A Multiparametric Approach Integrating Multimodal Ultrasound and Serum TPO-Ab for Differentiating Thyroid Carcinoma in Hashimoto's Thyroiditis: A Comparative Diagnostic Study with Internal Validation

Objectives To evaluate whether a multiparametric approach combining grayscale ultrasound (2D-US), contrast-enhanced ultrasound (CEUS), and serum anti-thyroid peroxidase antibody (TPO-Ab) improves the differentiation of benign from malignant thyroid nodules (TNs) in patients with Hashimoto's thyroiditis (HT) and to assess the stability of the combined diagnostic model through internal validation. Methods This retrospective study enrolled 600 HT patients with 650 pathologically confirmed TNs. All patients underwen…

Health · G Space — documented gain · certified 2026-09-09 · v1 · article view · machine-readable

Current reading — gain

A logistic regression model combining grayscale ultrasound, contrast-enhanced ultrasound, and serum TPO-Ab improved differentiation of benign versus malignant thyroid nodules in Hashimoto's thyroiditis, reaching cross-validated AUC 0.849 with 77.3% sensitivity and 77.8% specificity.

What this doesn’t fix

Model was developed retrospectively with internal validation only and has not been tested prospectively in external populations, limiting readiness for clinical use.

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Truvace Impact Record TRV-2026-1027, v1: “A Multiparametric Approach Integrating Multimodal Ultrasound and Serum TPO-Ab for Differentiating Thyroid Carcinoma in Hashimoto's Thyroiditis: A Comparative Diagnostic Study with Internal Validation.” Truvace, 2026-09-09. /record/TRV-2026-1027 (accessed at citation time). sha256 f1a3a9b728422d1f…

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