aceDevelopment of a machine-learning risk stratification tool for vasoactive medication need after two-bolus fluid resuscitation in pediatric suspected sepsis
Background Timely vasopressor initiation is critical in fluid-refractory pediatric septic shock, yet clinicians lack objective tools to identify children requiring early hemodynamic escalation after fluid resuscitation. Methods We performed a retrospective multicenter study using electronic health record data from five pediatric emergency departments (March 2022-February 2025). Children aged 3 months-17 years screened for sepsis who received ≥2 fluid boluses and were vasopressor-naïve at the second bolus were in…
A Random Forest model using eight routinely available variables predicted subsequent vasopressor need after two fluid boluses in pediatric suspected sepsis with AUROC 0.827 and stratified patients into four tiers with a 6.6% to 63.6% gradient.
Evidence
- Peer-reviewedPediatric Research2026-08-29
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Truvace Impact Record TRV-2026-0934, v1: “Development of a machine-learning risk stratification tool for vasoactive medication need after two-bolus fluid resuscitation in pediatric suspected sepsis.” Truvace, 2026-08-31. /record/TRV-2026-0934 (accessed at citation time). sha256 c9c27dcc9e8d863e…
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