Machine learning models trained on clinical, radiomics and dosiomics features predicted radionecrosis after stereotactic radiotherapy for brain metastases with ROC-AUC up to 80%, offering decision support that may improve patient-specific treatment and reduce radiotherapy-induced toxicity severity.
In a study published September 13, 2026, investigators applied eleven machine learning models to predict late radionecrosis after stereotactic radiotherapy for brain metastases. Using data from 37 patients with 113 lesions, where radionecrosis occurred in 18.6% of lesions, they tested four feature combinations of clinical, radiomics and dosiomics data after a 70:30 split and feature selection and balancing steps.
- Impact 30%
- 69
- Evidence 25%
- 95
- Scale 20%
- 35
- Confidence 15%
- 87
- Recency 10%
- 95
Updated Sep 15, 2026 · TRV-2026-1098
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