Interpretable random survival forest model predicted all-cause mortality in adults with unrepaired PAH-CHD and stratified survival in both Eisenmenger and non-Eisenmenger subgroups where the ESC model did not.
Researchers developed and internally validated an interpretable machine learning risk model for adults with unrepaired pulmonary arterial hypertension associated with congenital heart disease using data from 601 patients in a Chinese national prospective registry followed for a median 76 months. A random survival forest achieved a bootstrapping C-index of 0.773, and SHAP analysis highlighted predictors such as hemoglobin, BMI, systolic blood pressure, and diastolic pulmonary artery pressure to build new risk strata.
- Impact 30%
- 49
- Evidence 25%
- 95
- Scale 20%
- 85
- Confidence 15%
- 87
- Recency 10%
- 95
Updated Sep 14, 2026 · TRV-2026-1083
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