A six-protein plasma signature tested with SVM distinguished fibrotic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis on an independent test set with 71.4% accuracy, offering a non-invasive diagnostic aid.
Between July 2018 and June 2022, investigators enrolled 119 subjects across healthy controls, non-fibrotic HP, fibrotic HP, and IPF cohorts and performed plasma proteomic profiling with WGCNA. They identified 813 proteins, noted enrichment of glycolysis/gluconeogenesis and pyruvate metabolism in FHP, and distilled nine differential proteins to a six-protein signature that was used to train seven machine learning classifiers.
- Impact 30%
- 63
- Evidence 25%
- 95
- Scale 20%
- 35
- Confidence 15%
- 87
- Recency 10%
- 84
Updated Jul 19, 2026 · TRV-2026-0264
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