acePlasma proteomics and machine learning deliver non-invasive distinction between fibrotic hypersensitivity pneumonitis and idiopathic pulmonary fibrosis
Hypersensitivity pneumonitis (HP) manifests as fibrotic (FHP) and non-fibrotic (NFHP) phenotypes. Clinically distinguishing FHP from idiopathic pulmonary fibrosis (IPF) remains challenging owing to phenotypic overlap, despite divergent management protocols. This investigation sought to develop a plasma proteomics-based framework for differential diagnosis between these entities. A total of 119 subjects were enrolled from the Chinese Interstitial Lung Disease (ILD) National Cohort and the PORTRAY IPF Cohort betwe…
A six-protein plasma signature tested with SVM distinguished fibrotic hypersensitivity pneumonitis from idiopathic pulmonary fibrosis on an independent test set with 71.4% accuracy, offering a non-invasive diagnostic aid.
Evidence
- Peer-reviewedJournal of Translational Medicine2026-07-17
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Truvace Impact Record TRV-2026-0264, v1: “Plasma proteomics and machine learning deliver non-invasive distinction between fibrotic hypersensitivity pneumonitis and idiopathic pulmonary fibrosis.” Truvace, 2026-07-19. /record/TRV-2026-0264 (accessed at citation time). sha256 c1a1dc361a482a6b…
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