Integrating pFBA with DoubleML identified 17 hypertension-associated metabolites and a 19-species FERM guild whose metabolic flux contribution, not abundance, tracks blood pressure, pointing to microbiome intervention targets.
On 2026-08-04, a peer-reviewed mSystems study reported using pFBA combined with DoubleML and differential correlation network analysis to move beyond species-abundance comparisons in hypertension. The approach identified 17 metabolites associated with hypertension and a coordinated 19-member microbial module called the FERM guild whose functional contribution to those metabolites tracked blood pressure.
- Impact 30%
- 49
- Evidence 25%
- 95
- Scale 20%
- 35
- Confidence 15%
- 87
- Recency 10%
- 87
Updated Aug 5, 2026 · TRV-2026-0655
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