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TruaceTracing the truth around AIWednesday, August 5, 2026
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TRV-2026-0655Certified recordPeer-reviewed

The FERM guild: a differentially correlated microbial module drives hypertension via metabolic flux perturbations

Hypertension is a major risk factor for cardiovascular diseases, with changes in gut microbiota composition and function being closely associated with its onset and progression. However, the high inter-individual variability in gut microbiota complicates the identification of pathogenic mechanisms using traditional methods. In contrast, the smaller variability in gut microbial metabolites offers a more reliable and consistent basis for cross-individual comparisons. Parsimonious flux balance analysis (pFBA), inte…

Health · G Space — documented gain · certified 2026-08-05 · v1 · article view · machine-readable

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Integrating pFBA with DoubleML identified 17 hypertension-associated metabolites and a 19-species FERM guild whose metabolic flux contribution, not abundance, tracks blood pressure, pointing to microbiome intervention targets.

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Truvace Impact Record TRV-2026-0655, v1: “The FERM guild: a differentially correlated microbial module drives hypertension via metabolic flux perturbations.” Truvace, 2026-08-05. /record/TRV-2026-0655 (accessed at citation time). sha256 7047306a0f9ad067…

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