Logistic regression screening model using routine indicators like total protein and hemoglobin achieved AUC 0.843 and provides an accessible tool for early identification of individuals at high risk of M-protein in resource-limited primary care.
Researchers developed and validated an M-protein screening model using routine laboratory indicators from 5217 participants across three Chinese hospitals. They compared eight machine learning algorithms and selected a logistic regression model incorporating sex, age, total protein, albumin, albumin/globulin ratio, and hemoglobin, achieving an AUC of 0.843 in training and 0.843, 0.801, and 0.800 in internal and two external validations with a five-tier risk stratification.
- Impact 30%
- 49
- Evidence 25%
- 95
- Scale 20%
- 60
- Confidence 15%
- 87
- Recency 10%
- 92
Updated Aug 29, 2026 · TRV-2026-0924
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