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TRV-2026-0924Certified recordPeer-reviewed

Development and validation of a generalizable M-protein screening model using routine laboratory indicators: a multicenter retrospective study

Early detection of plasma cell disorders (PCDs) remains challenging due to limited accessibility of gold standard diagnostic methods. This study aimed to develop a simple M-protein screening model using routine laboratory indicators for clinical laboratories. A total of 5217 participants from three Chinese hospitals were enrolled. The derivation cohort (n = 3019) was randomly divided into training and internal validation cohorts. Two external validation cohorts (n = 1747 and n = 451) were included. M-protein pos…

Science · G Space — documented gain · certified 2026-08-29 · v1 · article view · machine-readable

Current reading — gain

Logistic regression screening model using routine indicators like total protein and hemoglobin achieved AUC 0.843 and provides an accessible tool for early identification of individuals at high risk of M-protein in resource-limited primary care.

What this doesn’t fix

Model development and validation were limited to participants from three Chinese hospitals, which may constrain generalizability to other populations and healthcare settings.

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Truvace Impact Record TRV-2026-0924, v1: “Development and validation of a generalizable M-protein screening model using routine laboratory indicators: a multicenter retrospective study.” Truvace, 2026-08-29. /record/TRV-2026-0924 (accessed at citation time). sha256 487d1db3d1a8388d…

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