Random survival forests models incorporating oxidative stress index score improved prediction of disease-free and overall survival for locally advanced rectal cancer patients receiving neoadjuvant therapy, outperforming conventional ypStage and enabling risk stratification.
Researchers developed a novel oxidative stress index score from liver enzyme biomarkers and built machine learning models to predict disease-free survival and overall survival in 970 locally advanced rectal cancer patients treated at Sun Yat-Sen University Cancer Center. The training cohort received total neoadjuvant therapy and the validation cohort received neoadjuvant chemoradiotherapy, followed by surgery.
- Impact 30%
- 49
- Evidence 25%
- 95
- Scale 20%
- 35
- Confidence 15%
- 87
- Recency 10%
- 88
Updated Aug 14, 2026 · TRV-2026-0754
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