A 16-gene macrophage-associated signature developed with ridge regression and XGBoost stratified HCC patients and achieved high diagnostic discrimination, with LGALS1 emerging as a top feature linked to survival and treatment response.
On August 22, 2026, researchers reported an integrative analysis combining single-cell RNA-sequencing with bulk transcriptomic and clinical data from TCGA-LIHC, GEO, and ICGC to find macrophage-associated biomarkers in hepatocellular carcinoma. They derived a 16-gene signature that stratified tumors by survival and clinicopathological features, with ridge regression showing AUC 0.988 in TCGA-LIHC and 0.895-0.924 externally, and XGBoost SHAP identifying LGALS1 as highly informative.
- Impact 30%
- 49
- Evidence 25%
- 95
- Scale 20%
- 35
- Confidence 15%
- 87
- Recency 10%
- 90
Updated Aug 24, 2026 · TRV-2026-0865
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