Artificial intelligence and radiologists in prostate cancer detection on MRI (PI-CAI): an international, paired, non-inferiority, confirmatory study
BACKGROUND: Artificial intelligence (AI) systems can potentially aid the diagnostic pathway of prostate cancer by alleviating the increasing workload, preventing overdiagnosis, and reducing the dependence on experienced radiologists. We aimed to investigate the performance of AI systems at detecting clinically significant prostate cancer on MRI in comparison with radiologists using the Prostate Imaging-Reporting and Data System version 2.1 (PI-RADS 2.1) and the standard of care in multidisciplinary routine pract…
When compared to historical multidisciplinary routine practice readings in 1000 testing cases, the AI system did not demonstrate confirmed non-inferiority and showed slightly lower specificity at matched sensitivity.
Retrospective design and need for prospective testing; authors note clinical applicability not yet established.
Evidence
- Peer-reviewedThe Lancet Oncology2024-06-12
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Truvace Impact Record TRV-2026-0402, v1: “Artificial intelligence and radiologists in prostate cancer detection on MRI (PI-CAI): an international, paired, non-inferiority, confirmatory study.” Truvace, 2026-07-20. /record/TRV-2026-0402 (accessed at citation time). sha256 2e2a27b44c9339bc…
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