An unsupervised AI framework discovered a 13-marker cellular morphometric signature from colorectal whole-slide images that transferred to gastric and esophageal cancers and enabled risk stratification of precancerous lesions and early-stage cancers to guide surveillance and intervention.
Researchers developed an unsupervised, interpretable AI framework to define tissue-agnostic cellular morphometric biomarkers that capture conserved tumor microenvironment organization across gastrointestinal organs. Discovered in colorectal cancer slides and validated in gastric and esophageal cancers in a 2,602-patient multi-center cohort, a 13-marker signature showed prognostic value and enabled risk stratification of precancerous lesions and early-stage cancers.
- Impact 30%
- 49
- Evidence 25%
- 95
- Scale 20%
- 35
- Confidence 15%
- 87
- Recency 10%
- 91
Updated Aug 26, 2026 · TRV-2026-0890
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