+ HEALTH Aims Intramuscular fat (IMF) is increasingly recognized as a marker of ectopic adiposity and adverse cardiome…+ HEALTH Periapical lesions are challenging to detect on intraoral radiographs because of anatomical superimposition a…± HEALTH Ultrasound imaging is an indispensable diagnostic tool, yet its profound reliance on operator expertise inher…+ HEALTH Objectives We adapted the individualized polysocial risk score (iPsRS), a machine learning model originally d…± HEALTH Melioidosis is a life-threatening infectious disease caused by Burkholderia pseudomallei ( Bp ). Rapid diagno…+ HEALTH Classification is a core machine learning task, and ensemble voting methods are widely used to improve predic…+ CLIMATE Microplastic (MP) pollution poses escalating environmental risks, demanding efficient and reproducible tools…± HEALTH Medicinal chemistry sits at the center of modern drug discovery, yet translating molecular designs into appro…
TruaceTracing the truth around AIWednesday, August 26, 2026
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TRV-2026-0890Certified recordPeer-reviewed

Tissue-Agnostic Cellular Morphometric Biomarkers for Risk-Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

While precision oncology increasingly adopts tissue-agnostic paradigms, current strategies remain heavily reliant on molecular alterations, with limited relevance to early-stage cancers and precancerous lesion management. Here we present an unsupervised and interpretable artificial intelligence framework that defines tissue-agnostic cellular morphometric biomarkers (CMBs) capturing conserved tumor microenvironment (TME) architectures associated with cancer progression across gastrointestinal (GI) organs. Discove…

Health · G Space — documented gain · certified 2026-08-26 · v1 · article view · machine-readable

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An unsupervised AI framework discovered a 13-marker cellular morphometric signature from colorectal whole-slide images that transferred to gastric and esophageal cancers and enabled risk stratification of precancerous lesions and early-stage cancers to guide surveillance and intervention.

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Truvace Impact Record TRV-2026-0890, v1: “Tissue-Agnostic Cellular Morphometric Biomarkers for Risk-Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers.” Truvace, 2026-08-26. /record/TRV-2026-0890 (accessed at citation time). sha256 d4fa5a873ad46fb5…

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