Systematic review found most ML algorithms improved CVD risk prediction compared with Framingham Risk Score by incorporating sociodemographic predictors and modeling non-linear interactions.
A systematic review published 12 September 2026 searched three databases to 1 January 2025 and included 29 studies that directly compared machine learning CVD risk predictions with the Framingham Risk Score in healthy adults. Twenty-three studies reported improved predictive ability, often by adding sociodemographic predictors absent from FRS or costly diagnostics such as CT angiography.
- Impact 30%
- 49
- Evidence 25%
- 95
- Scale 20%
- 35
- Confidence 15%
- 87
- Recency 10%
- 95
Updated Sep 14, 2026 · TRV-2026-1081
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