aceGene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk
Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood. We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort. Methods We analysed subsets of 488 079 UK Biobank participants with metabolomic and proteomic profiling, cardiac magnetic resonance (CMR) imaging,…
Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk: An exposome-wide association study identified environmental determinants of inflammation, and gene-environment interactions were assessed using multi-ancestry polygenic risk scores.
Evidence
- Peer-reviewedEuropean Journal of Preventive Cardiology2026-09-18
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Truvace Impact Record TRV-2026-1143, v2: “Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk.” Truvace, 2026-10-26. /record/TRV-2026-1143 (accessed at citation time). sha256 dad2bc0612579446…
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