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Climate·P Space·Evidence-backed problem·Published 2026-09-19

Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk

Abstract: Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood. We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort. Methods We analysed subsets of 488 079 UK Biobank participants with metabolomic and proteomic profiling, cardiac magnetic resonance (CMR) imaging,…

TRV-2026-1143Peer-reviewedPermanent record — cite & verify
Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk

Host-diet-gut microbiome interactions influence human energy balance- a randomized clinical trial by Karen D. Corbin, Elvis A. Carnero, Blake Dirks, Daria Igudesman, Fanchao Yi, Andrew Marcus, Taylor L. Davis, Richard E. Pratley, Bruce E. Rittmann, Rosa Krajmalnik-Brown & Steven R. Smith. CC BY 4.0 · https://creativecommons.org/licenses/by/4.0

The quick read

Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood. We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort.

Machine learning-based analysis extracted CMR phenotypes.

Main points
  • Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood.
  • We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort.
  • Methods We analysed subsets of 488 079 UK Biobank participants with metabolomic and proteomic profiling, cardiac magnetic resonance (CMR) imaging, and longitudinal outcomes.
Problem

Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk: An exposome-wide association study identified environmental determinants of inflammation, and gene-environment interactions were assessed using multi-ancestry polygenic risk scores.

The rundown

Methods We analysed subsets of 488 079 UK Biobank participants with metabolomic and proteomic profiling, cardiac magnetic resonance (CMR) imaging, and longitudinal outcomes. Chronic inflammation was quantified using glycoprotein acetyls (GlycA) by nuclear magnetic resonance spectroscopy.

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