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Study links environment and genes to inflammation that raises heart disease risk

Study title: Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk

Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood. We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort.

Read the study abstract

Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood. We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort. Methods We analysed subsets of 488 079 UK Biobank participants with metabolomic and proteomic profiling, cardiac magnetic resonance (CMR) imaging,…

By the Truvace desk1 min read1 sourceEvidence: Moderate · 65/100 — Observational study · n = 488,079 · 1 independent sourcePeer-reviewedTRV-2026-1143· cite & verify
Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk
Host-diet-gut microbiome interactions influence human energy balance- a randomized clinical trial by Karen D. Corbin, Elvis A. Carnero, Blake Dirks, Daria Igudesman, Fanchao Yi, Andrew Marcus, Taylor L. Davis, Richard E. Pratley, Bruce E. Rittmann, Rosa Krajmalnik-Brown & Steven R. Smith. CC BY 4.0 · https://creativecommons.org/licenses/by/4.0

In brief

Machine learning-based analysis extracted CMR phenotypes.

Main points

  1. Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood.
  2. We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort.
  3. Methods We analysed subsets of 488 079 UK Biobank participants with metabolomic and proteomic profiling, cardiac magnetic resonance (CMR) imaging, and longitudinal outcomes.

The problem

Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk: An exposome-wide association study identified environmental determinants of inflammation, and gene-environment interactions were assessed using multi-ancestry polygenic risk scores.

The rundown

Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood. We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort.

Methods We analysed subsets of 488 079 UK Biobank participants with metabolomic and proteomic profiling, cardiac magnetic resonance (CMR) imaging, and longitudinal outcomes. Chronic inflammation was quantified using glycoprotein acetyls (GlycA) by nuclear magnetic resonance spectroscopy.

Sources

  1. Peer-reviewedEuropean Journal of Preventive Cardiology2026-09-18

The debate