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TRV-2026-1143Version 1 · Certified

Written 2026-09-19 06:53:37 UTC · current record

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TRUVACE RECORD VERSION
record: TRV-2026-1143
version: 1
kind: certified
reason: Certified into the record
timestamp: 2026-09-19T06:53:37.652794Z
status: published
lens: p_space
sector: climate
headline: Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk
dek: Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood. We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort. Methods We analysed subsets of 488 079 UK Biobank participants with metabolomic and proteomic profiling, cardiac magnetic resonance (CMR) imaging,…
gain_title: (none)
problem_title: Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk: An exposome-wide association study identified environmental determinants of inflammation, and gene-environment interactions were assessed using multi-ancestry polygenic risk scores.
trace_subject: (none)
gain_reading: (none)
gain_evidence: (none)
problem_reading: Gene-environment interactions shape cytokine-mediated inflammation and cardiovascular risk: An exposome-wide association study identified environmental determinants of inflammation, and gene-environment interactions were assessed using multi-ancestry polygenic risk scores.
problem_evidence: (none)
quick_read: Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood. We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort.

Machine learning-based analysis extracted CMR phenotypes.
limitation: 
tag: Evidence-backed problem
key_points: Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood. | We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort. | Methods We analysed subsets of 488 079 UK Biobank participants with metabolomic and proteomic profiling, cardiac magnetic resonance (CMR) imaging, and longitudinal outcomes.
rundown: Background Chronic inflammation is a major driver of cardiovascular diseases, but mechanisms linking systemic inflammation to cardiac remodelling remain incompletely understood. We aimed to evaluate the role of cytokine-mediated signalling and the influence of environmental and genetic factors on inflammation and cardiac phenotypes in a large population-based cohort.

Methods We analysed subsets of 488 079 UK Biobank participants with metabolomic and proteomic profiling, cardiac magnetic resonance (CMR) imaging, and longitudinal outcomes. Chronic inflammation was quantified using glycoprotein acetyls (GlycA) by nuclear magnetic resonance spectroscopy.
sources:
- peer_reviewed | European Journal of Preventive Cardiology | https://doi.org/10.1093/eurjpc/zwag435 | 2026-09-18
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