aceHighly accurate protein structure prediction with AlphaFold
Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort 1-4 , the structures of around 100,000 unique proteins have been determined 5 , but this represents a small fraction of the billions of known protein sequences 6,7 . Structural coverage is bottlenecked by the months to years of painstaking effort required to determine a single protein structure. Accurate computational approaches are needed to addr…
AlphaFold provides a computational method that regularly predicts protein three-dimensional structures with atomic accuracy from amino acid sequence alone, even without homologous structures.
Evidence
- Peer-reviewedNature2021-07-15
- Peer-reviewedInternational Journal of Molecular Sciences2024-08-01
- Peer-reviewedMolecules2024-02-13
- Peer-reviewedNature Methods2024-12-02
- Peer-reviewedGenome Biology2023-05-12
How should this claim be treated?
Truvace Impact Record TRV-2026-0203, v5: “Highly accurate protein structure prediction with AlphaFold.” Truvace, 2026-07-19. /record/TRV-2026-0203 (accessed at citation time). sha256 b087136fe5703e47…
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