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Labor·P Space·Evidence-backed problem·Published 2026-09-05

Unmasking bias in the evidence ecosystem: a panoramic analysis of 311,751 meta-analyses using an artificial intelligence agent-based approach

Abstract: Traditional secondary meta-analysis workflows are highly labour-intensive, time-consuming, and difficult to update in real time. Currently, there is a lack of comprehensive artificial intelligence frameworks capable of automating the entire meta-analysis workflow, including literature screening, data extraction, and quality assessment. Furthermore, a large-scale structured database for systematically analysing the global landscape of published meta-analyses remains unavailable. In this viewpoint, we aimed to eva…

TRV-2026-0983Peer-reviewedPermanent record — cite & verify
Unmasking bias in the evidence ecosystem: a panoramic analysis of 311,751 meta-analyses using an artificial intelligence agent-based approach

N-gram analysis results – top 20 recurrent 4-g for the 137 descriptions of "privacy" in AI governance guidelines by Authors of the study: Nicholas Kluge Corrêa Camila Galvão James William Santos Carolina Del Pino Edson Pontes Pinto Camila Barbosa Diogo Massmann Rodrigo Mambrini Luiza Galvão Edmund Terem Nythamar de Oliveira. CC BY 4.0 · https://creativecommons.org/licenses/by/4.0

The quick read

Traditional secondary meta-analysis workflows are highly labour-intensive, time-consuming, and difficult to update in real time. Currently, there is a lack of comprehensive artificial intelligence frameworks capable of automating the entire meta-analysis workflow, including literature screening, data extraction, and quality assessment.

In this viewpoint, we aimed to evaluate the feasibility of large language models in automating meta-analysis workflows and develop the Meta-Analysis Screening, Transformation and Evaluation Review Agent (MASTER) agent; establish a large-scale Unified Meta-Analysis Repository (UMAR) and perform an exploratory panoramic analysis of the current evidence ecosystem; and develop an Agent-based Secondary Meta-analysis Platform (ASAP), integrating these capabilities. Here, we provide an initial exploration of the technical feasibility and scalability of artificial intelligence-driven automated meta-analysis.

Main points
  • Traditional secondary meta-analysis workflows are highly labour-intensive, time-consuming, and difficult to update in real time.
  • Currently, there is a lack of comprehensive artificial intelligence frameworks capable of automating the entire meta-analysis workflow, including literature screening, data extraction, and quality assessment.
  • Furthermore, a large-scale structured database for systematically analysing the global landscape of published meta-analyses remains unavailable.
Problem

Currently, there is a lack of comprehensive artificial intelligence frameworks capable of automating the entire meta-analysis workflow, including literature screening, data extraction, and quality assessment.

The rundown

Furthermore, a large-scale structured database for systematically analysing the global landscape of published meta-analyses remains unavailable. In this viewpoint, we aimed to evaluate the feasibility of large language models in automating meta-analysis workflows and develop the Meta-Analysis Screening, Transformation and Evaluation Review Agent (MASTER) agent; establish a large-scale Unified Meta-Analysis Repository (UMAR) and perform an exploratory panoramic analysis of the current evidence ecosystem; and develop an Agent-based Secondary Meta-analysis Platform (ASAP), integrating these capabilities.

Sources

Reader signal

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The debate