+ HEALTH Background Discharge letters are essential for continuity of care, yet patients often misunderstand their con…± HEALTH Hematoxylin and Eosin (H&E) glass slide preparation is fundamental to histopathology. Pathologists' expertise…+ CLIMATE Traditional soil heavy metal risk assessments suffer from fragmented indices and poor logical integration. Co…± HEALTH Background Neonatal pneumothorax can progress rapidly, yet detection on supine chest radiographs remains chal…+ HEALTH T cell exhaustion has widespread implications for the progression and treatment of chronic diseases including…+ HEALTH Background Standard pulmonary arterial hypertension (PAH) risk models may not fully apply to PAH associated w…+ HEALTH Objectives To map and synthesize the scientific evidence regarding the use of Augmented Reality (AR) and Mixe…± HEALTH Objective To examine whether the outputs of machine learning algorithms designed to predict risk of cardiovas…

+ HEALTH Background Discharge letters are essential for continuity of care, yet patients often misunderstand their con…± HEALTH Hematoxylin and Eosin (H&E) glass slide preparation is fundamental to histopathology. Pathologists' expertise…+ CLIMATE Traditional soil heavy metal risk assessments suffer from fragmented indices and poor logical integration. Co…± HEALTH Background Neonatal pneumothorax can progress rapidly, yet detection on supine chest radiographs remains chal…+ HEALTH T cell exhaustion has widespread implications for the progression and treatment of chronic diseases including…+ HEALTH Background Standard pulmonary arterial hypertension (PAH) risk models may not fully apply to PAH associated w…+ HEALTH Objectives To map and synthesize the scientific evidence regarding the use of Augmented Reality (AR) and Mixe…± HEALTH Objective To examine whether the outputs of machine learning algorithms designed to predict risk of cardiovas…

Health · Drug Discovery

All Diagnostics & Imaging Drug Discovery Mental Health Hospitals & Care

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Model-prefilled problem

Embedded transparency in artificial intelligence: a prerequisite for equity and representation in AI-enabled clinical trials

Artificial intelligence is being embedded in clinical trial infrastructure, shaping who is identified, stratified, and analysed. Opaque models risk amplifying existing disparities in the evidence base. We argue that embedded transparency, the structural integration of ex ante interpretability, demographic auditability, documented uncertainty handling, and stakeholder-relative explanation, is a necessary, though not sufficient, condition for equitable AI-enabled trials, and propose governance recommendations acti…

npj Digital Medicine · Health

Embedded transparency in artificial intelligence: a prerequisite for equity and representation in AI-enabled clinical trials

Predictive value of the uric acid to high-density cholesterol ratio (UHR) combined with intact parathyroid hormone for protein-energy wasting after incident hemodialysis: a multicenter study

Evidence-backed gain

Predictive value of the uric acid to high-density cholesterol ratio (UHR) combined with intact parathyroid hormone for protein-energy wasting after incident hemodialysis: a multicenter study

Protein-energy wasting (PEW) is common in incident hemodialysis patients and linked to poor outcomes. The uric acid/HDL-cholesterol ratio (UHR) and intact parathyroid hormone (iPTH) relate to metabolic, inflammatory, and nutritional disturbances, but their value for predicting PEW in incident hemodialysis is unclear. This retrospective multicenter study included 863 incident hemodialysis patients. PEW was defined according to the International Society of Renal Nutrition and Metabolism criteria. UHR and iPTH were…

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