aceArtificial intelligence-enabled clinical phenotyping of human brown fat
Adipose tissue has a central role in systemic energy balance and the pathogenesis of obesity and its sequelae 1,2 . In contrast to white adipose tissue, brown adipose tissue (BAT) uses energy to produce heat 3 . Detectable BAT in humans is associated with decreased prevalence of cardiometabolic diseases 4 . However, the complete spectrum of health conditions associated with BAT remains unknown, and high-throughput methods to quantify BAT activity in humans are lacking 5,6 . Here we leveraged big data and artific…
Machine learning let researchers semi-automatically measure brown fat activity in about 8,700 patients, linking higher activity to lower odds of cardiometabolic disease and pointing to losartan as a candidate for activating the tissue.
The brown fat findings are described as associations in a cohort drawn from a single large cancer centre, and the losartan result is presented only as proof of concept.
Evidence
- Peer-reviewedNature2026-10-14
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Truvace Impact Record TRV-2026-2130, v1: “Artificial intelligence-enabled clinical phenotyping of human brown fat.” Truvace, 2026-10-21. /record/TRV-2026-2130 (accessed at citation time). sha256 a7965409246d2b3b…
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