aceMultiscale model calibrated with a Bayesian algorithm predicts long-term outcomes of treatments for mitral valve regurgitation in animal models
In primary mitral valve regurgitation (MR), a failing valve induces volume overload (VO) of the left ventricle (LV), triggering neurohormonal responses and myocardial remodeling. Surgical valve repair is the most effective therapy for MR, improving symptoms and in some patients reversing cardiac hypertrophy. However, at least 20% of patients develop postoperative impairment of LV function with detrimental effects on long-term outcomes, with no known cause. Many MR patients receive pharmacological treatment to al…
A Bayesian-calibrated multiscale model predicted long-term outcomes of mitral regurgitation treatments in animal models, integrating data from 76 studies.
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- Peer-reviewedBiomechanics and Modeling in Mechanobiology2026-09-20
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Truvace Impact Record TRV-2026-1157, v3: “Multiscale model calibrated with a Bayesian algorithm predicts long-term outcomes of treatments for mitral valve regurgitation in animal models.” Truvace, 2026-11-04. /record/TRV-2026-1157 (accessed on the day you copy it). sha256 90302a1dcde98bf5…
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Editorial pass: sharper headline; filed as context: no real AI gain or problem (gain activity_only, problem absent).
Direction audit: filed as a problem but describes a gain.
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