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TRV-2026-1130Certified recordPeer-reviewed

Deep Learning-Powered Plasmonic Platform for Decoding Dynamic Protein Aggregation Landscapes in Parkinson's Disease Progression

In-depth characterization of pathological protein aggregate with its subcomponents is pivotal for early diagnosis and staging of neurodegenerative disorders. Here, we introduce the Protein Aggregate NanoDynamics Analyzer (PANDA), a plasmonic nanotechnology-powered system that translates the supramolecular size distribution of protein aggregates into distinct scattering signatures via sterically constrained immunogold clustering. In this work, PANDA enabled the profiling of α-synuclein (α-syn) aggregates with div…

Health · G Space — documented gain · certified 2026-09-18 · v1 · article view · machine-readable

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Deep learning-augmented plasmonic system PANDA profiled alpha-synuclein aggregate size distributions from human serum and classified Parkinson's disease stages with correlation to clinical scores and dopaminergic PET imaging.

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Truvace Impact Record TRV-2026-1130, v1: “Deep Learning-Powered Plasmonic Platform for Decoding Dynamic Protein Aggregation Landscapes in Parkinson's Disease Progression.” Truvace, 2026-09-18. /record/TRV-2026-1130 (accessed at citation time). sha256 a6abef1335b68615…

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