aceCurrent quality challenges in H&E preparation: The critical foundation for increased use of digital pathology and AI emergence
Hematoxylin and Eosin (H&E) glass slide preparation is fundamental to histopathology. Pathologists' expertise routinely mitigates potential issues due to quality variability into or across laboratories, ensuring diagnostic accuracy. However, as artificial intelligence (AI) induced by whole slide imaging (WSI) emerges as a future advancement in pathology, a shift toward greater technical standardisation of the preparations or adaptive algorithms deserves consideration. This study examined longitudinal data (2019-…
Up to a quarter of H&E slides in French labs showed technical preparation imperfections and up to 23.8% showed suboptimal staining, creating inconsistent inputs that undermine robust AI performance from whole slide imaging.
Findings are bounded to the French EQA system and vary by tissue type and year, limiting generalizability to other countries or lab networks.
Evidence
- Peer-reviewedVirchows Archiv2026-09-12
How should this claim be treated?
Truvace Impact Record TRV-2026-1087, v2: “Current quality challenges in H&E preparation: The critical foundation for increased use of digital pathology and AI emergence.” Truvace, 2026-10-26. /record/TRV-2026-1087 (accessed at citation time). sha256 af286b8ba1f9e7ac…
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