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TRV-2026-0998Certified recordPeer-reviewed

The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells

N- (1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPD-Q), a tire rubber antioxidant derivative, accumulates in air, soil, and water and has been found in urine, blood, and cerebrospinal fluid, posing significant health risks. Although 6PPD-Q exhibits intestinal toxicity, its role in inflammatory bowel disease (IBD) remains unclear. The objective of this study was to identify key molecular targets of 6PPD-Q in IBD and to validate their involvement in 6PPD-Q-induced intestinal epithelial cell injury. U…

Health · The Trace — both readings · certified 2026-09-06 · v1 · article view · machine-readable

Current reading — gain

Multi-model machine learning screening of 6PPD-Q-IBD targets identified 60 overlapping targets and prioritized six core genes with NR1H4 as a key mediator of intestinal epithelial injury.

Current reading — problem

Machine learning-informed toxicology analysis indicates 6PPD-quinone exposure increases IBD risk in human colon epithelial cells by downregulating NR1H4, causing lipid and cholesterol accumulation, mitochondrial dysfunction, and elevated IL-6, TNF-alpha, and IL-8.

What this doesn’t fix

Findings are limited to computational screening and in vitro human intestinal epithelial cell experiments without in vivo or clinical IBD patient validation.

Evidence

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Truvace Impact Record TRV-2026-0998, v1: “The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells.” Truvace, 2026-09-06. /record/TRV-2026-0998 (accessed at citation time). sha256 30a93e65deb73d74…

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