Local Recurrence Prediction After Carbon-ion Radiotherapy for Early-stage Non-small Cell Lung Cancer Using Machine Learning
Background/aim Predicting local recurrence remains challenging in carbon-ion radiotherapy (CIRT) for non-small cell lung cancer (NSCLC). In this study, we aimed to develop and validate a machine learning model to predict local recurrence after CIRT for early-stage peripheral NSCLC. Patients and methods We retrospectively analyzed patients treated with CIRT at our institution between 2010 and 2020. An Extreme Gradient Boosting classifier using clinical parameters was developed to predict local recurrence within 2…
Clinical-parameter XGBoost model stratified patients into low-risk and high-risk groups with 94.0% vs 65.0% 2-year local control after carbon-ion radiotherapy for early-stage peripheral NSCLC.
Retrospective single-institution study with only 124 patients and 10 recurrence events, and modest discriminative performance limits generalizability.
Evidence
- Peer-reviewedAnticancer Research2026-08-01
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Truvace Impact Record TRV-2026-0622, v1: “Local Recurrence Prediction After Carbon-ion Radiotherapy for Early-stage Non-small Cell Lung Cancer Using Machine Learning.” Truvace, 2026-08-02. /record/TRV-2026-0622 (accessed at citation time). sha256 82418ef08b2d18ce…
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