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Health·P Space·Evidence-backed problem·Published 2026-09-20

Artificial Intelligence in Cerebral Small Vessel Disease Imaging: A Study-Level Cross-Sectional Analysis of Validation Status and Clinical Applicability

Abstract: Artificial intelligence (AI) is increasingly used in cerebral small vessel disease (CSVD) imaging, but the extent of validation and clinical applicability across the literature remains uncertain. We performed a study-level cross-sectional analysis using a frozen Web of Science Core Collection (WoSCC) cohort supplemented by PubMed and IEEE Xplore searches to assess database coverage and the stability of findings from the WoSCC cohort. After study-level reconciliation, 463 independent studies were included. White…

TRV-2026-1149Peer-reviewedPermanent record — cite & verify
Artificial Intelligence in Cerebral Small Vessel Disease Imaging: A Study-Level Cross-Sectional Analysis of Validation Status and Clinical Applicability

Essays on ear and throat diseases [electronic resource] : ear disease in childhood, ear disease and life assurance, certain peculiar aural and cerebral symptoms, diseases of the tonsils and uvula requiring operation by Thomas, Llewelyn. Public domain

The quick read

Artificial intelligence (AI) is increasingly used in cerebral small vessel disease (CSVD) imaging, but the extent of validation and clinical applicability across the literature remains uncertain. We performed a study-level cross-sectional analysis using a frozen Web of Science Core Collection (WoSCC) cohort supplemented by PubMed and IEEE Xplore searches to assess database coverage and the stability of findings from the WoSCC cohort.

White matter hyperintensity segmentation/quantification was the most common task (196/463, 42.3%), followed by cerebral microbleed detection/classification (82/463, 17.7%), perivascular space/lacune assessment (67/463, 14.5%), CSVD burden/risk modeling (62/463, 13.4%), and clinical outcome prediction (56/463, 12.1%). Deep learning was the largest model family (185/463, 40.0%).

Main points
  • Artificial intelligence (AI) is increasingly used in cerebral small vessel disease (CSVD) imaging, but the extent of validation and clinical applicability across the literature remains uncertain.
  • We performed a study-level cross-sectional analysis using a frozen Web of Science Core Collection (WoSCC) cohort supplemented by PubMed and IEEE Xplore searches to assess database coverage and the stability of findings from the WoSCC cohort.
  • After study-level reconciliation, 463 independent studies were included.
Problem

Artificial Intelligence in Cerebral Small Vessel Disease Imaging: A Study-Level Cross-Sectional Analysis of Validation Status and Clinical Applicability: White matter hyperintensity segmentation/quantification was the most common task (196/463, 42.3%), followed by cerebral microbleed detection/classification (82/463, 17.7%), perivascular space/lacune assessment (67/463, 14.5%), CSVD burden/risk modeling (62/463, 13.4%), and clinical outcome prediction (56/463, 12.1%).

The rundown

After study-level reconciliation, 463 independent studies were included. White matter hyperintensity segmentation/quantification was the most common task (196/463, 42.3%), followed by cerebral microbleed detection/classification (82/463, 17.7%), perivascular space/lacune assessment (67/463, 14.5%), CSVD burden/risk modeling (62/463, 13.4%), and clinical outcome prediction (56/463, 12.1%).

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