All stories

1338 published stories · page 33 of 90

Adaptation of a fair individualized polysocial risk score for hospitalization risk prediction
Evidence-backed gain

Adaptation of a fair individualized polysocial risk score for hospitalization risk prediction

Objectives We adapted the individualized polysocial risk score (iPsRS), a machine learning model originally developed for patients with type 2 diabetes, to evaluate its generalizability in predicting 1-year hospitalization risk in a disease-agnostic adult cohort, with attention to fairness and explainability. Materials and methods The study utilized de-identified electronic health record data from a retrospective cohort of 17 857 adult patients at the University of Florida Health. The original iPsRS framework wa…

Diagnosing melioidosis and tracking treatment outcomes using breath
Both readings

Diagnosing melioidosis and tracking treatment outcomes using breath

Melioidosis is a life-threatening infectious disease caused by Burkholderia pseudomallei ( Bp ). Rapid diagnosis and appropriate antimicrobial treatment are critical to reduce mortality, yet diagnosis is hindered by diverse clinical manifestations, mimicry with other diseases, and reliance on slow culture-based methods. Detecting volatile compounds offers a non-invasive approach for rapid infection detection. In this study, we aim to identify volatile compounds in patients' breath that can aid in diagnosing meli…

Dynamic F1-score-based voting strategies for multi-class classification: an adaptive ensemble approach for non-linear and imbalanced datasets
Evidence-backed gain

Dynamic F1-score-based voting strategies for multi-class classification: an adaptive ensemble approach for non-linear and imbalanced datasets

Classification is a core machine learning task, and ensemble voting methods are widely used to improve predictive accuracy in domains such as medical diagnosis, where class imbalance and non-linear decision boundaries are common. Conventional strategies: Majority Voting (MV), Weighted Voting (WV), and Soft Voting (SV) rely on static or classifier-level weighting schemes that fail to capture per-class differences in classifier reliability. Three dynamic, class-specific voting strategies are introduced: Highest Cl…

Developing and evaluating automated deep learning and human-in-the-loop vision-language systems for microplastic characterization
Evidence-backed gain

Developing and evaluating automated deep learning and human-in-the-loop vision-language systems for microplastic characterization

Microplastic (MP) pollution poses escalating environmental risks, demanding efficient and reproducible tools for morphological characterization of plastic particles. Traditional manual microscopy is labour-intensive, operator-dependent, and poorly suited to large-scale monitoring. This study presents a comparative evaluation of two distinct artificial intelligence paradigms for the analysis of optical microscope images of microplastics. The first paradigm is a domain-specific, multi-task deep learning (DL) class…

Health

AI-powered medicinal chemistry and translational drug development

Medicinal chemistry sits at the center of modern drug discovery, yet translating molecular designs into approved medicines remains slow, expensive, and prone to high attrition across the pipeline from target identification to clinical validation. Artificial intelligence (AI) is beginning to reshape this landscape by enabling large-scale integration, interpretation, and generation of chemical, biological, and clinical data for hypothesis generation, chemical space exploration, and iterative cycles of model-guided…

AI-powered medicinal chemistry and translational drug development
Health

The Importance of Artificial Intelligence in Nursing: A Fundamentals of Care Perspective

Aim To analyze the integration of Artificial Intelligence in nursing through the lens of the Fundamentals of Care framework. Design A discursive paper. Methods This discursive paper synthesizes current literature and theoretical perspectives to examine the Relationship, Integration and Context dimensions of the Fundamentals of Care framework in the era of Artificial Intelligence. Results Artificial Intelligence offers substantial benefits in optimizing workflow (Context) and clinical precision (Integration) thro…

The Importance of Artificial Intelligence in Nursing: A Fundamentals of Care Perspective
Health

Assessing the Utility of Social Determinants of Health Data in Suicide Prediction Models

Objective This study seeks to explore the utility of social determinants of health (SDoH) variables in suicide prediction models. We aim to assess the impact of individual- and geographic-level SDoH factors on improving the performance of suicide prediction models and the identification of individuals at high risk for suicide. Methods A retrospective sample of 1214 deaths by suicide and 815,544 living patients was identified in the Maryland Suicide Data Warehouse (MSDW) and linked to census tract data through ge…

Assessing the Utility of Social Determinants of Health Data in Suicide Prediction Models
Health

Tissue-Agnostic Cellular Morphometric Biomarkers for Risk-Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

While precision oncology increasingly adopts tissue-agnostic paradigms, current strategies remain heavily reliant on molecular alterations, with limited relevance to early-stage cancers and precancerous lesion management. Here we present an unsupervised and interpretable artificial intelligence framework that defines tissue-agnostic cellular morphometric biomarkers (CMBs) capturing conserved tumor microenvironment (TME) architectures associated with cancer progression across gastrointestinal (GI) organs. Discove…

Tissue-Agnostic Cellular Morphometric Biomarkers for Risk-Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers
Crime

Forensic analysis of dominant versus non-dominant handwriting: Statistical and machine learning insights

Systematic, paired quantitative evidence on how handwriting changes when the non-dominant hand is used remains limited in forensic document examination, despite its frequent relevance in cases involving disguise and authorship concealment. This study presents the first large-scale within-writer analysis examining general and individual handwriting characteristics using statistical testing and predictive modeling. Handwriting samples were collected from 94 right-handed participants, each of whom produced the same…

Forensic analysis of dominant versus non-dominant handwriting: Statistical and machine learning insights