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1338 published stories · page 31 of 90

Clinical phenotyping of bloodstream infections: a review of current evidence
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Clinical phenotyping of bloodstream infections: a review of current evidence

Bloodstream infections (BSIs) are a leading cause of morbidity and mortality, yet their clinical heterogeneity continues to challenge effective patient stratification and treatment optimisation. In other heterogeneous conditions such as sepsis, data-driven clinical subphenotyping has identified reproducible subgroups with distinct outcomes and treatment responses. Whether similar approaches can be applied to BSIs to improve clinical management and trial design is an area of growing interest. We aimed to review t…

Quantitative decoupling of source-pathway-receptor driving mechanisms for integrated soil risk via interpretable machine learning
Evidence-backed gain

Quantitative decoupling of source-pathway-receptor driving mechanisms for integrated soil risk via interpretable machine learning

Most existing concentration-based risk assessments of potentially toxic elements (PTEs) in farmland soils tend to overlook source-specific transport pathways and receptor-related risks. In this study, an integrated risk index-machine learning framework based on the source-pathway-receptor concept is developed to comprehensively evaluate PTE risks in a typical mining city. The framework integrates the improved Nemerow index (INI), potential ecological risk index, Monte Carlo simulation-based health risk assessmen…

Development and validation of a generalizable M-protein screening model using routine laboratory indicators: a multicenter retrospective study
Evidence-backed gain

Development and validation of a generalizable M-protein screening model using routine laboratory indicators: a multicenter retrospective study

Early detection of plasma cell disorders (PCDs) remains challenging due to limited accessibility of gold standard diagnostic methods. This study aimed to develop a simple M-protein screening model using routine laboratory indicators for clinical laboratories. A total of 5217 participants from three Chinese hospitals were enrolled. The derivation cohort (n = 3019) was randomly divided into training and internal validation cohorts. Two external validation cohorts (n = 1747 and n = 451) were included. M-protein pos…

Climate

Is the environmental impact of datacentres finally cutting through?

Anti-datacentre sentiment is growing from across the political spectrum in the US. More than a dozen states have considered moratoria on datacentres. New York became the first US state to enact a temporary ban last month. Progressive stalwarts Senator Bernie Sanders and Representative Alexandria Ocasio-Cortez have proposed a national moratorium. And even Greg Abbott, the far-right governor of Texas, called for a ban on datacentre development in rural swaths of his state. Fuelling alarm about datacentres are envi…

Is the environmental impact of datacentres finally cutting through?
Health

Association between body composition and recurrence in stage II-III colon cancer: a retrospective cohort study

Colorectal Cancer (CRC) is a common cause of cancer death and prognostic factors are used to determine management. Patients with advanced disease often become cachectic, losing skeletal muscle mass and density, as well as subcutaneous fat. CT can be used to assess body composition by measuring skeletal muscle area, density and subcutaneous and visceral fat. We hypothesise that evidence of sarcopenia or myosteatosis at diagnosis is associated with an increased risk of cancer recurrence. Patients discussed at the…

Association between body composition and recurrence in stage II-III colon cancer: a retrospective cohort study
Health

An Interpretable Machine Learning Framework with Clinical Nomogram for Predicting In-Hospital Mortality in Acute Ischemic Stroke Using High-Granularity Bedside Data

This multicenter study developed and validated an interpretable machine learning model integrating granular nursing and emergency department data collected within the first 24 hours to predict in-hospital mortality in acute ischemic stroke (AIS). We analyzed a retrospective cohort of 5,014 adult AIS patients from three tertiary academic centers (2019-2023). Centers A and B (n=3,512) formed the development cohort; Center C (n=1,502) served as the external validation cohort. Sixty-three predictors across seven dom…

An Interpretable Machine Learning Framework with Clinical Nomogram for Predicting In-Hospital Mortality in Acute Ischemic Stroke Using High-Granularity Bedside Data
Health

TrialScout links published results to trial registrations using a large language model

Multiple stakeholders need to locate results of registered clinical trials but frequently struggle to find them. Summary results of clinical trials are often not published in trial registries, and publications containing trial results are often not explicitly linked to their respective trial registrations. Finding these results is important to researchers, systematic reviewers, research funders, regulators, clinical practitioners, and patients. We developed TrialScout, a computer program that uses a large langua…

TrialScout links published results to trial registrations using a large language model
Health

Noninvasive Profiling of the Glioma Vascular Microenvironment via 7T MRI: Decoding Angiogenic Signatures for Isocitrate Dehydrogenase and World Health Organization Grade Differentiation

Accurate preoperative glioma grading and molecular subtyping are important for treatment. The vascular microenvironment promotes tumor progression. A noninvasive screening tool capable of mapping tumor vascularity may assist in preoperative grading and subtyping of gliomas. To evaluate 7T susceptibility-weighted imaging (SWI) for differentiating glioma isocitrate dehydrogenase (IDH) status and World Health Organization (WHO) grade based on vascular microenvironment features. Retrospective. Among 218 patients wit…

Noninvasive Profiling of the Glioma Vascular Microenvironment via 7T MRI: Decoding Angiogenic Signatures for Isocitrate Dehydrogenase and World Health Organization Grade Differentiation