Tissue-Agnostic Cellular Morphometric Biomarkers for Risk-Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers
While precision oncology increasingly adopts tissue-agnostic paradigms, current strategies remain heavily reliant on molecular alterations, with limited relevance to early-stage cancers and precancerous lesion management. Here we present an unsupervised and interpretable artificial intelligence framework that defines tissue-agnostic cellular morphometric biomarkers (CMBs) capturing conserved tumor microenvironment (TME) architectures associated with cancer progression across gastrointestinal (GI) organs. Discove…
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