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An informatics framework to harmonize electronic health record medication data for managed care analytics and artificial intelligence applications
HealthContested · G 68 / P 65

harmonizing heterogeneous EHR medication identifiers into standardized RxCUI ingredient and ATC representations to enable managed care AI analytics

Source article: An informatics framework to harmonize electronic health record medication data for managed care analytics and artificial intelligence applications

Problem

Heterogeneous NDC, Multum, and RxCUI identifiers in real-world EHRs undermined semantic consistency, with over half of records needing string reconciliation and up to 57.4% requiring correction due to branded formulation omissions and indication- or route-based ATC ambiguities.

Journal of Managed Care & Specialty Pharmacy
Gain

A two-layered RxCUI ingredient and ATC framework harmonized 214,080 discharge medication records from older adults into standardized representations, achieving 100% initial mapping via deterministic crosswalks to support transportable managed care AI tools.

Journal of Managed Care & Specialty Pharmacy
A pharmacist-overseen, artificial intelligence-enabled model for provider-side prior authorization: From burden to opportunity (PAVE-1)
HealthNegative state · G 64 / P 71

AI-enabled automation of prior authorization in managed care pharmacy

Source article: A pharmacist-overseen, artificial intelligence-enabled model for provider-side prior authorization: From burden to opportunity (PAVE-1)

Problem

Use of AI to automate prior authorization raises concerns about transparency, bias, and overreliance, with payer-deployed systems potentially denying claims without adequate clinical review.

Journal of Managed Care & Specialty Pharmacy
Gain

A pharmacist-overseen AI system for provider organizations could reduce prescriber workload and increase first-pass approval rates by automating routine data extraction and submissions while routing complex cases to pharmacists.

Journal of Managed Care & Specialty Pharmacy
[Artificial intelligence in cardiovascular prevention: a strategic opportunity for risk prediction and early diagnosis]
HealthContested · G 71 / P 68

AI for cardiovascular risk prediction and early diagnosis in preventive cardiology

Source article: [Artificial intelligence in cardiovascular prevention: a strategic opportunity for risk prediction and early diagnosis]

Problem

Implementation of AI for cardiovascular prevention remains limited by insufficient prospective evidence and randomized trials, lack of validation in heterogeneous populations, limited model interpretability, and inadequate digital and regulatory infrastructures, leaving a gap between guideline recommendations and real‑

Giornale Italiano di Cardiologia
Gain

AI models improve cardiovascular prevention by providing more precise, dynamic and personalized risk stratification than traditional scores and by enabling early detection of subclinical atrial fibrillation, left ventricular dysfunction and coronary disease through AI-enabled ECG and opportunistic imaging.

Giornale Italiano di Cardiologia
Artificial Intelligence in Xenotransplantation: A Prioritized Roadmap for Early Clinical Translation, Opportunities and Challenges
HealthContested · G 70 / P 74

AI-based support systems for early clinical xenotransplantation

Source article: Artificial Intelligence in Xenotransplantation: A Prioritized Roadmap for Early Clinical Translation, Opportunities and Challenges

Problem

AI application in xenotransplantation is limited by lack of clinical data, species-specific differences, and missing standardized definitions and ground truth datasets for xenograft injury.

Xenotransplantation
Gain

AI-based support systems could enhance safety and make xenotransplantation more reproducible when combined with gene-edited donors and refined immunosuppression.

Xenotransplantation
Multisite Implementation of a Digital Wound Model of Care: A Post-Implementation Multimethods Evaluation of Patient and Clinician Perspectives and Lessons Learned
HealthNegative state · G 69 / P 76

patient experience of the AI-enabled digital wound model of care

Source article: Multisite Implementation of a Digital Wound Model of Care: A Post-Implementation Multimethods Evaluation of Patient and Clinician Perspectives and Lessons Learned

Problem

Only 59% of patients felt meaningfully involved in decisions about their own care, and clinicians reported implementation barriers including poor connectivity, time pressures and training burden.

International Wound Journal
Gain

District-wide implementation of an AI-enabled wound app with virtual command centre produced high patient satisfaction and perceived benefit, including improved communication and self-management confidence among app users.

International Wound Journal
A machine learning-derived sarcopenia index is associated with survival and nonrelapse mortality in DLBCL
HealthContested · G 74 / P 72

machine learning-derived CT body composition assessment of sarcopenia and survival outcomes in DLBCL patients receiving immunochemotherapy

Source article: A machine learning-derived sarcopenia index is associated with survival and nonrelapse mortality in DLBCL

Problem

In DLBCL patients treated with first-line immunochemotherapy, CT-measured sarcopenia in the lowest tertile of muscle mass is associated with inferior overall survival driven by nonrelapse mortality and higher risk of hematologic toxicity.

Blood Advances
Gain

Machine learning-supported body composition analysis applied to CT imaging quantifies radiologic sarcopenia and enables risk stratification for survival after first-line immunochemotherapy in newly diagnosed DLBCL.

Blood Advances
Advancing hirschsprung disease diagnosis: a systematic review of the development and application of artificial intelligence in histopathological analysis
HealthPositive state · G 77 / P 72

AI-assisted histopathological diagnosis of Hirschsprung disease

Source article: Advancing hirschsprung disease diagnosis: a systematic review of the development and application of artificial intelligence in histopathological analysis

Problem

69% of studies showed high risk of bias from small sample sizes, patch-level data partitioning, and no external test sets, raising concerns about overfitting and data leakage.

Pediatric Surgery International
Gain

Deep learning models for Hirschsprung disease histopathology achieved over 90% ganglion cell detection and cut diagnostic time by 50-95%, increasing accuracy and accelerating clinical decision-making.

Pediatric Surgery International
Mapping agricultural fragility in India through a yield gap vulnerability framework: a national-scale machine learning assessment
CrimeContested · G 69 / P 72

district-level agricultural vulnerability to yield gaps in India assessed by ML-based YGV framework

Source article: Mapping agricultural fragility in India through a yield gap vulnerability framework: a national-scale machine learning assessment

Problem

Despite increased modal yields for rice and wheat, regional yield gaps continue to widen and the share of high-vulnerability districts has risen, particularly in resource-stressed regions such as the Indo-Gangetic Plains, driven by socioeconomic inequality and climate variability.

Journal of Environmental Management
Gain

The integrated ML-based Yield Gap Vulnerability framework provides a data-driven decision-support tool that can support sustainable agricultural management, spatial planning and risk reduction by identifying vulnerability hotspots for region-specific measures in India.

Journal of Environmental Management
The Role of Artificial Intelligence Models in Predicting Post-Prosthetic Facial Esthetics in Edentulous Patients: Clinical and Anthropometric Comparative Study
HealthContested · G 70 / P 66

AI prediction of post-denture facial esthetics in edentulous patients

Source article: The Role of Artificial Intelligence Models in Predicting Post-Prosthetic Facial Esthetics in Edentulous Patients: Clinical and Anthropometric Comparative Study

Problem

AI simulations failed to accurately reproduce quantitative facial anthropometric changes after denture placement despite visual similarity.

European Journal of Dentistry
Gain

AI models Gemini and FaceApp generated post-denture facial images rated as esthetically comparable to actual clinical outcomes by patients and experts.

European Journal of Dentistry
Automated artificial intelligence performance for longitudinal pulmonary nodule matching in lung cancer screening
HealthContested · G 67 / P 70

automated longitudinal matching of persisting pulmonary nodules >=100 mm3 in UKLS 3-month follow-up LDCT

Source article: Automated artificial intelligence performance for longitudinal pulmonary nodule matching in lung cancer screening

Problem

Automated matching failed for 16.5% of persisting findings and performance fell to 72.8% in participants with more than five nodules, with prospective validation in diverse populations still needed.

European Radiology
Gain

Automated pulmonary AI matched persisting lung nodules across 3-month LDCT scans with 83.5% success, reaching 91.8% for single-nodule cases and leaving only 1.5% of persisting findings needing manual correction, indicating potential to reduce manual tracking workload.

European Radiology
Machine learning for monitoring and assessment of potentially toxic elements in soils: a synthesis of spatial validation, explainability, and uncertainty
ClimateContested · G 69 / P 72

machine learning mapping of potentially toxic elements in soils for monitoring and risk assessment

Source article: Machine learning for monitoring and assessment of potentially toxic elements in soils: a synthesis of spatial validation, explainability, and uncertainty

Problem

Many ML studies of soil potentially toxic elements rely on spatially naive validation, and random cross-validation often overestimates predictive performance when spatial dependence is ignored, with incomplete uncertainty reporting.

Environmental Monitoring and Assessment
Gain

Machine learning can map potentially toxic element concentrations from environmental covariates and produce exceedance-probability maps aligned with regulatory thresholds for soil-contamination management.

Environmental Monitoring and Assessment
Clinical phenotyping of bloodstream infections: a review of current evidence
HealthContested · G 70 / P 66

data-driven clinical subphenotyping of bloodstream infections to stratify mortality risk and guide therapy

Source article: Clinical phenotyping of bloodstream infections: a review of current evidence

Problem

Studies use inconsistent phenotyping methods and provide limited validation, slowing translation of AI-derived BSI subphenotypes into routine clinical practice.

Clinical Microbiology and Infection
Gain

Unsupervised machine learning applied to bloodstream infections identifies reproducible clinical subphenotypes with different mortality, supporting bedside tools for rapid phenotype assignment and personalized antimicrobial therapy.

Clinical Microbiology and Infection
Association between body composition and recurrence in stage II-III colon cancer: a retrospective cohort study
HealthContested · G 70 / P 67

machine-learning-derived myosteatosis as predictor of recurrence in stage II-III colon cancer

Source article: Association between body composition and recurrence in stage II-III colon cancer: a retrospective cohort study

Problem

Patients with stage II-III colon cancer whose CT body composition showed myosteatosis via machine learning analysis had significantly lower 5-year recurrence-free survival.

Clinical Nutrition ESPEN
Gain

Using a machine learning model to measure CT body composition at L3 identified myosteatosis as an independent predictor of recurrence in stage II-III colon cancer.

Clinical Nutrition ESPEN
Reinventing the echocardiography workflow: from manual quantification to artificial intelligence-driven comprehensive interpretation
HealthContested · G 72 / P 74

AI-driven echocardiography workflow and its effects on examination performance and clinical implementation

Source article: Reinventing the echocardiography workflow: from manual quantification to artificial intelligence-driven comprehensive interpretation

Problem

Clinical use of AI in echocardiography carries risk of automation bias in high-volume settings, compounded by inconsistent performance across platforms.

Journal of Cardiovascular Imaging
Gain

AI integration in echocardiography workflows reduces examination time and automates measurements, enabling more comprehensive data collection while reducing sonographer fatigue.

Journal of Cardiovascular Imaging
Naïve adaptive immune receptor repertoires in celiac disease assessed by machine learning; impact of the HLA-DQ2.5 allotype on the TCR repertoire
HealthContested · G 68 / P 68

machine-learning classification of celiac disease status from naive adaptive immune receptor repertoires

Source article: Naïve adaptive immune receptor repertoires in celiac disease assessed by machine learning; impact of the HLA-DQ2.5 allotype on the TCR repertoire

Problem

After accounting for HLA-DQ2.5 enrichment, machine-learning classification of celiac disease from naive TCR repertoires was abolished, and naive BCR repertoires failed to classify disease.

Immunogenetics
Gain

Naive CD4+ TCR repertoire features enabled moderate machine-learning classification of celiac disease status and high-accuracy prediction of HLA-DQ2.5 status by publication date.

Immunogenetics