aceDiagnosing melioidosis and tracking treatment outcomes using breath
Melioidosis is a life-threatening infectious disease caused by Burkholderia pseudomallei ( Bp ). Rapid diagnosis and appropriate antimicrobial treatment are critical to reduce mortality, yet diagnosis is hindered by diverse clinical manifestations, mimicry with other diseases, and reliance on slow culture-based methods. Detecting volatile compounds offers a non-invasive approach for rapid infection detection. In this study, we aim to identify volatile compounds in patients' breath that can aid in diagnosing meli…
Machine learning analysis of breath volatiles identified candidate markers that discriminated culture-confirmed melioidosis from other febrile illnesses with perfect AUC in a small test set and tracked culture status and treatment time during antibiotics.
In extended testing, the three-marker panel misclassified one febrile control, and the overall pilot size limits generalizability for rapid diagnosis.
Pilot design with very small discovery cohorts (n=7 vs n=6 for initial discrimination) and total n=25, so findings are candidate markers requiring larger validation before clinical use.
Evidence
- Peer-reviewedJournal of Breath Research2026-08-25
How should this claim be treated?
Truvace Impact Record TRV-2026-0896, v1: “Diagnosing melioidosis and tracking treatment outcomes using breath.” Truvace, 2026-08-26. /record/TRV-2026-0896 (accessed at citation time). sha256 8c432829cbf8c0c1…
Calibration history
Every change to this record since certification, in the open. None yet — the reading has held since it entered the record.
Certified into the record
How to verify without trusting this page
Fetch the canonical text of any version from /api/record/TRV-2026-0896 and hash it yourself — for example shasum -a 256 on the saved canonical field. The result must equal content_hash, and each version’s text ends with prev:followed by the prior version’s hash (version 1 chains to 64 zeros). If a single character of any version had been altered since certification, the chain would not reproduce.