Prompt-dependent readability and accuracy of Generative Pre-trained Transformer-5 thinking responses to breast imaging questions derived from European Society of Breast Imaging patient recommendations

Purpose: Although professional societies provide standardized resources, the reliability of online health content remains inconsistent, particularly as large language models (LLMs) become a growing source of patient information. Therefore, the primary objective of this study was to determine whether patient-focused prompt optimization improves the readability of Generative Pre-trained Transformer-5 (GPT-5) Thinking responses compared with standard prompting while evaluating potential changes in expert-rated fact…