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ProblemPublished recordHealthProblem Space

Machine learning algorithms for predicting PTSD: a systematic review and meta-analysis

Truvace record
TRV-2026-2753raw data (JSON)
Version
v1Published
First published
Evidence type
Systematic review or meta-analysis
Sources
1 sourcePeer-reviewed
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41a49c010593…check it

Abstract This study aimed to compare and evaluate the prediction accuracy and risk of bias (ROB) of post-traumatic stress disorder (PTSD) predictive models. We conducted a systematic review and random-effect meta-analysis summarizing predictive model development and validation studies using machine learning in diverse samples to predict PTSD. Model performances were pooled using the area under the curve (AUC) with a 95% confidence interval (CI). Heterogeneity in each meta-analysis was measured using I2. The risk…

The problem

A systematic review of 23 machine learning studies predicting PTSD found none had low risk of bias (11 high, 12 unclear), and in medical-trauma populations external validation of tree-based models pooled an AUC of 0.591.

What this doesn’t fix

The authors say high heterogeneity among the included studies limits how the results can be interpreted. The review also excluded non-English papers and did not search EMBASE or the Cochrane Library, so some eligible studies may be missing.

Sources

1 on file
  1. Peer-reviewed2025-01-21

What the review found when it combined the studies

These are the review’s own pooled results, copied from its abstract. Truvace did not recalculate them.

  • PTSD prediction by tree-based models in people with alcohol-related stress

    AUC 0.935 (95% CI 0.914 to 0.956)

    The review’s own words
    Similarly, in populations with alcohol-related stress, these models produced a pooled AUC of 0.935 (95% CIs 0.914–0.956, I 2 = 97.55%).
  • PTSD prediction by ensemble methods in the general population

    AUC 0.841 (95% CI 0.783 to 0.898)

    The review’s own words
    In general PTSD populations, the meta-analysis included SVM, ensemble methods, and linear models, recording pooled AUCs of 0.824 (95% CIs 0.778–0.871, I 2 = 0%), 0.841 (95% CIs 0.783–0.898, I 2 = 0%), and 0.768 (95% CIs 0.608–0.928, I 2 = 60.06%), respectively.
  • PTSD prediction by linear models in people with medical trauma

    AUC 0.828 (95% CI 0.717 to 0.939)

    The review’s own words
    In the context of medical trauma, analyses were conducted for two algorithms, revealing pooled AUCs of 0.828 (95% CIs 0.717–0.939, I 2 = 98.18%) for linear models and 0.808 (95% CIs 0.761–0.855, I 2 = 95.25%) for tree-based models.
  • PTSD prediction by tree-based models in people with war or military experience

    AUC 0.745 (95% CI 0.572 to 0.917)

    The review’s own words
    Specifically, tree-based models achieved a pooled AUC of 0.745 (95% CIs 0.572–0.917, I 2 = 97.31%), compared to 0.615 (95% CIs 0.552–0.768, I 2 = 0%) for neural networks.
  • PTSD prediction by tree-based models in people with sexual or physical trauma

    AUC 0.861 (95% CI 0.723 to 1)

    The review’s own words
    For individuals with experiences of sexual or physical trauma, the employment of tree-based models resulted in a pooled AUC of 0.861 (95% CIs 0.723–1, I 2 = 96.78%).
  • PTSD prediction by tree-based models in people with medical trauma

    AUC 0.808 (95% CI 0.761 to 0.855)

    The review’s own words
    In the context of medical trauma, analyses were conducted for two algorithms, revealing pooled AUCs of 0.828 (95% CIs 0.717–0.939, I 2 = 98.18%) for linear models and 0.808 (95% CIs 0.761–0.855, I 2 = 95.25%) for tree-based models.
  • PTSD prediction by tree-based models in firefighters

    AUC 0.96 (95% CI 0.918 to 1)

    The review’s own words
    Among firefighters, tree-based models achieved the highest pooled AUC across all examined demographics, at 0.96 (95% CIs 0.918–1, I 2 = 99.98%).
  • PTSD prediction by tree-based models after natural disasters

    AUC 0.771 (95% CI 0.755 to 0.787)

    The review’s own words
    Tree-based models led with a pooled AUC of 0.771 (95% CIs 0.755–0.787, I 2 = 90.41%), closely followed by linear models with an AUC of 0.768 (95% CIs 0.764–0.771, I 2 = 78.76%).
  • PTSD prediction by neural networks in people with war or military experience

    AUC 0.615 (95% CI 0.552 to 0.768)

    The review’s own words
    Specifically, tree-based models achieved a pooled AUC of 0.745 (95% CIs 0.572–0.917, I 2 = 97.31%), compared to 0.615 (95% CIs 0.552–0.768, I 2 = 0%) for neural networks.
  • External validation of tree-based models predicting PTSD in people with medical trauma

    AUC 0.591 (95% CI 0.47 to 0.712)

    The review’s own words
    External validation of tree-based models in this demographic reported a pooled AUC of 0.591 (95% CIs 0.47–0.712, I 2 = 93.61%).

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v1

Truvace Impact Record TRV-2026-2753, v1: “Machine learning algorithms for predicting PTSD: a systematic review and meta-analysis.” Truvace, 2026-11-12. /record/TRV-2026-2753 (accessed on the day you copy it). sha256 41a49c01059352b5…

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