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Machine learning algorithms for predicting PTSD: a systematic review and meta-analysis
- Truvace record
- TRV-2026-2753raw data (JSON)
- Version
- v1Published
- First published
- Evidence type
- Systematic review or meta-analysis
- Sources
- 1 sourcePeer-reviewed
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Abstract This study aimed to compare and evaluate the prediction accuracy and risk of bias (ROB) of post-traumatic stress disorder (PTSD) predictive models. We conducted a systematic review and random-effect meta-analysis summarizing predictive model development and validation studies using machine learning in diverse samples to predict PTSD. Model performances were pooled using the area under the curve (AUC) with a 95% confidence interval (CI). Heterogeneity in each meta-analysis was measured using I2. The risk…
The problem
A systematic review of 23 machine learning studies predicting PTSD found none had low risk of bias (11 high, 12 unclear), and in medical-trauma populations external validation of tree-based models pooled an AUC of 0.591.
What this doesn’t fix
The authors say high heterogeneity among the included studies limits how the results can be interpreted. The review also excluded non-English papers and did not search EMBASE or the Cochrane Library, so some eligible studies may be missing.
Sources
1 on file- BMC Medical Informatics and Decision Makingdoi:10.1186/s12911-024-02754-2
What the review found when it combined the studies
These are the review’s own pooled results, copied from its abstract. Truvace did not recalculate them.
PTSD prediction by tree-based models in people with alcohol-related stress
AUC 0.935 (95% CI 0.914 to 0.956)
The review’s own words
Similarly, in populations with alcohol-related stress, these models produced a pooled AUC of 0.935 (95% CIs 0.914–0.956, I 2 = 97.55%).
PTSD prediction by ensemble methods in the general population
AUC 0.841 (95% CI 0.783 to 0.898)
The review’s own words
In general PTSD populations, the meta-analysis included SVM, ensemble methods, and linear models, recording pooled AUCs of 0.824 (95% CIs 0.778–0.871, I 2 = 0%), 0.841 (95% CIs 0.783–0.898, I 2 = 0%), and 0.768 (95% CIs 0.608–0.928, I 2 = 60.06%), respectively.
PTSD prediction by linear models in people with medical trauma
AUC 0.828 (95% CI 0.717 to 0.939)
The review’s own words
In the context of medical trauma, analyses were conducted for two algorithms, revealing pooled AUCs of 0.828 (95% CIs 0.717–0.939, I 2 = 98.18%) for linear models and 0.808 (95% CIs 0.761–0.855, I 2 = 95.25%) for tree-based models.
PTSD prediction by tree-based models in people with war or military experience
AUC 0.745 (95% CI 0.572 to 0.917)
The review’s own words
Specifically, tree-based models achieved a pooled AUC of 0.745 (95% CIs 0.572–0.917, I 2 = 97.31%), compared to 0.615 (95% CIs 0.552–0.768, I 2 = 0%) for neural networks.
PTSD prediction by tree-based models in people with sexual or physical trauma
AUC 0.861 (95% CI 0.723 to 1)
The review’s own words
For individuals with experiences of sexual or physical trauma, the employment of tree-based models resulted in a pooled AUC of 0.861 (95% CIs 0.723–1, I 2 = 96.78%).
PTSD prediction by tree-based models in people with medical trauma
AUC 0.808 (95% CI 0.761 to 0.855)
The review’s own words
In the context of medical trauma, analyses were conducted for two algorithms, revealing pooled AUCs of 0.828 (95% CIs 0.717–0.939, I 2 = 98.18%) for linear models and 0.808 (95% CIs 0.761–0.855, I 2 = 95.25%) for tree-based models.
PTSD prediction by tree-based models in firefighters
AUC 0.96 (95% CI 0.918 to 1)
The review’s own words
Among firefighters, tree-based models achieved the highest pooled AUC across all examined demographics, at 0.96 (95% CIs 0.918–1, I 2 = 99.98%).
PTSD prediction by tree-based models after natural disasters
AUC 0.771 (95% CI 0.755 to 0.787)
The review’s own words
Tree-based models led with a pooled AUC of 0.771 (95% CIs 0.755–0.787, I 2 = 90.41%), closely followed by linear models with an AUC of 0.768 (95% CIs 0.764–0.771, I 2 = 78.76%).
PTSD prediction by neural networks in people with war or military experience
AUC 0.615 (95% CI 0.552 to 0.768)
The review’s own words
Specifically, tree-based models achieved a pooled AUC of 0.745 (95% CIs 0.572–0.917, I 2 = 97.31%), compared to 0.615 (95% CIs 0.552–0.768, I 2 = 0%) for neural networks.
External validation of tree-based models predicting PTSD in people with medical trauma
AUC 0.591 (95% CI 0.47 to 0.712)
The review’s own words
External validation of tree-based models in this demographic reported a pooled AUC of 0.591 (95% CIs 0.47–0.712, I 2 = 93.61%).
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v1Truvace Impact Record TRV-2026-2753, v1: “Machine learning algorithms for predicting PTSD: a systematic review and meta-analysis.” Truvace, 2026-11-12. /record/TRV-2026-2753 (accessed on the day you copy it). sha256 41a49c01059352b5…
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