aceKnow Your DUCs: Direct Unequal Cleavage Subtypes Are Associated with Distinct Preimplantation Developmental Patterns
Background/Objectives: Direct unequal cleavage (DUC) is generally considered a marker of poor embryo competence. However, increasing evidence suggests that DUC represents a heterogeneous group of developmental abnormalities rather than a single biological entity. This study aimed to characterize developmental differences among individual DUC subtypes and to descriptively explore implantation and live-birth outcomes in the subset of transferred embryos. Methods: This retrospective study included 1381 DUC embryos…
AI-assisted identification and scoring of direct unequal cleavage embryos supported a finer-grained assessment, separating low-blastulation subtypes from higher-blastulation ones.
The clinical outcome sample was small and highly selected, so it cannot support comparisons of reproductive potential between subtypes, and larger studies are needed to establish prognosis.
Evidence
- Peer-reviewedReproductive Medicine2026-10-22
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Truvace Impact Record TRV-2026-2190, v1: “Know Your DUCs: Direct Unequal Cleavage Subtypes Are Associated with Distinct Preimplantation Developmental Patterns.” Truvace, 2026-10-22. /record/TRV-2026-2190 (accessed at citation time). sha256 f0949df84f61f5d2…
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