aceMachine Learning Models Combining [<sup>68</sup>Ga]Ga-PSMA-11 PET Radiomics and Clinical Features to Predict Overall Survival for Metastatic Castration-resistant Prostate Cancer Treated with [<sup>177</sup>Lu]Lu-PSMA Radioligand Therapy
Purpose Metastatic castration-resistant prostate cancer (mCRPC) remains incurable despite recent therapeutic advances. [ 177 Lu]Lu-PSMA RLT (lutetium-177 labelled prostate-specific membrane antigen radioligand therapy) provides meaningful clinical benefit in selected patients. However, ∼30% of the patients do not respond to [ 177 Lu]Lu-PSMA RLT. Although several baseline prognostic factors are well known, reliable pretherapeutic predictive biomarkers are still lacking. We developed and compared several predictiv…
Multimodal machine learning models using pretreatment PET radiomics plus clinical data predicted 12-month survival in mCRPC patients on Lu-PSMA therapy, with a best AUC of 0.778, which could help stratify patients.
The study was retrospective and conducted at a single center with 102 patients, which limits how far the findings can be generalized.
Evidence
- Peer-reviewedEuropean Urology Oncology2026-10-15
How should this claim be treated?
Truvace Impact Record TRV-2026-1964, v1: “Machine Learning Models Combining [<sup>68</sup>Ga]Ga-PSMA-11 PET Radiomics and Clinical Features to Predict Overall Survival for Metastatic Castration-resistant Prostate Cancer Treated with [<sup>177</sup>Lu]Lu-PSMA Radioligand Therapy.” Truvace, 2026-10-20. /record/TRV-2026-1964 (accessed at citation time). sha256 345e7c81d27e1fcf…
Calibration history
Every change to this record since certification, in the open. None yet — the reading has held since it entered the record.
Certified into the record
How to verify without trusting this page
Fetch the canonical text of any version from /api/record/TRV-2026-1964 and hash it yourself — for example shasum -a 256 on the saved canonical field. The result must equal content_hash, and each version’s text ends with prev:followed by the prior version’s hash (version 1 chains to 64 zeros). If a single character of any version had been altered since certification, the chain would not reproduce.