aceMachine learning-based prediction of malignant transformation within 5 years in patients with oral leukoplakia: A retrospective cohort study
Oral leukoplakia (OLK), a potentially malignant oral disorder, has 7.2 - 9.8 % transformation rate. Identifying high-risk patients within 5 years can reduce the oral cancer burden. In this retrospective study, we aimed to identify the factors associated with malignant transformation in Chinese patients with OLK and develop and evaluate machine learning (ML) models for predicting malignant transformation within 5 years. In total, 672 OLK patients (203 showing transformation; 469 with no transformation) were inclu…
Models trained on clinicopathological features discriminated which oral leukoplakia patients would develop malignancy within 5 years, which may support individualized risk stratification.
The temporal validation cohort was small and the models need testing in larger multicenter cohorts before any clinical use.
Evidence
- Peer-reviewedOral Oncology2026-10-17
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Truvace Impact Record TRV-2026-1956, v1: “Machine learning-based prediction of malignant transformation within 5 years in patients with oral leukoplakia: A retrospective cohort study.” Truvace, 2026-10-20. /record/TRV-2026-1956 (accessed at citation time). sha256 1ff95fc4de5c1470…
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