aceIntraoperative fluorescence spectroscopy for IDH classification in glioma: a feasibility study
Background Molecular features are fundamental to both the diagnosis and prognosis of gliomas. Specific molecular features are generally unavailable at the time of index surgery; however, upfront knowledge of molecular characteristics could meaningfully inform surgical strategy. Aims/objectives To determine the feasibility of a machine learning model trained on fluorescence spectral features to classify IDH mutation and MGMT promoter methylation status in glioma tissue. Methods Tissue samples were collected durin…
In a 27-patient pilot, a machine learning model trained on 5-ALA fluorescence spectra identified IDH-mutant glioma samples with 87% accuracy, suggesting possible real-time intraoperative molecular guidance.
The same model could not reliably classify MGMT promoter methylation status, so the approach did not extend to this second molecular marker.
This is a proof-of-concept study in only 27 patients, and the authors say larger cohorts and integration of 1p/19q status are still needed; MGMT methylation could not be reliably classified.
Evidence
- Peer-reviewedBritish Journal of Neurosurgery2026-10-09
How should this claim be treated?
Truvace Impact Record TRV-2026-1678, v1: “Intraoperative fluorescence spectroscopy for IDH classification in glioma: a feasibility study.” Truvace, 2026-10-17. /record/TRV-2026-1678 (accessed at citation time). sha256 8e4e32c533781dcf…
Calibration history
Every change to this record since certification, in the open. None yet — the reading has held since it entered the record.
Certified into the record
How to verify without trusting this page
Fetch the canonical text of any version from /api/record/TRV-2026-1678 and hash it yourself — for example shasum -a 256 on the saved canonical field. The result must equal content_hash, and each version’s text ends with prev:followed by the prior version’s hash (version 1 chains to 64 zeros). If a single character of any version had been altered since certification, the chain would not reproduce.