aceIntegration of liquid chromatography-tandem mass spectrometry into total laboratory automation: technical challenges and clinical advantages
The clinical laboratory is undergoing a paradigm shift toward the integration of liquid chromatography-tandem mass spectrometry(MS) into Total Laboratory Automation workflows. While historically relegated to specialized satellite units due to manual pre-analytical requirements, recent technological advancements have enabled the development of fully automated, 'sample-to-result' MS modules. This review provides an authoritative analysis of the technical integration of systems such as the Roche cobas® i 601 and Sh…
Integration of artificial intelligence-assisted middleware into total laboratory automation enables standardized validation and improves diagnostic accuracy for low-concentration analytes in endocrinology and therapeutic drug monitoring.
Evidence
- Peer-reviewedClinical Biochemistry2026-10-03
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Truvace Impact Record TRV-2026-1319, v1: “Integration of liquid chromatography-tandem mass spectrometry into total laboratory automation: technical challenges and clinical advantages.” Truvace, 2026-10-10. /record/TRV-2026-1319 (accessed at citation time). sha256 1ae5c63690a4d4dd…
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