aceIdentifying incident medication-related osteonecrosis of the jaw and antiresorptive drug holidays using natural language processing on clinical notes in men and women prescribed bisphosphonates or denosumab for fracture prevention
Objective Medication-related osteonecrosis of the jaw (MRONJ) is a rare complication of antiresorptive therapy for osteoporosis, with risk potentially influenced by "drug holidays" around dentoalveolar procedures. MRONJ risk is higher in rheumatic diseases. Epidemiologic studies are limited by poor administrative code performance for MRONJ identification and lack of structured pharmacy data capturing drug holidays. We developed and validated a natural language processing (NLP) algorithm to classify MRONJ and det…
NLP model classified incident MRONJ and identified antiresorptive drug holidays from free-text EHR notes with high precision and recall in validation sets.
Validation was limited to U.S. Veterans Health Administration EHR for adults >=50 prescribed bisphosphonates or denosumab, and MRONJ is described as rare, constraining generalizability and epidemiologic power.
Evidence
- Peer-reviewedArthritis Care & Research2026-10-03
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Truvace Impact Record TRV-2026-1272, v1: “Identifying incident medication-related osteonecrosis of the jaw and antiresorptive drug holidays using natural language processing on clinical notes in men and women prescribed bisphosphonates or denosumab for fracture prevention.” Truvace, 2026-10-04. /record/TRV-2026-1272 (accessed at citation time). sha256 30c2420728e8b6ba…
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