aceIntegrated Multi-Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC
Ductal carcinoma in situ (DCIS) is a non-invasive precursor of invasive ductal carcinoma (IDC), yet the biological mechanisms underlying the transition from DCIS to IDC remain incompletely understood. Here, we integrate spatial transcriptomics, single-cell RNA sequencing, and single-cell DNA sequencing on coexisting DCIS and IDC samples to characterize cellular and microenvironmental alterations. Integrated analyses reveal differential molecular characterizations between coexisting DCIS and IDC and identify cand…
Researchers built and externally validated a machine learning model that identifies DCIS at high risk of progressing to invasive disease, enabling more precise risk stratification and clinical management.
Evidence
- Peer-reviewedAdvanced Science2026-09-27
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Truvace Impact Record TRV-2026-1224, v1: “Integrated Multi-Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC.” Truvace, 2026-09-30. /record/TRV-2026-1224 (accessed at citation time). sha256 1f212812ae09651f…
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