aceThe impact of frailty and its changes on the development of motoric cognitive risk syndrome in middle-aged and older adults
Background Previous research links frailty to cognitive decline, but the relationship between frailty and motoric cognitive risk syndrome (MCR), a dementia precursor, is underexplored. Methods This study used CHARLS data with 3388 participants aged ≥45. Data from 2011 to 2012, 2013, and 2015 were analyzed to examine the relationship between frailty index (FI), total FI, and changes in FI (△FI) with MCR risk. Nine machine learning models were built using baseline FI to predict MCR risk, and changes in frailty sta…
Nine machine learning models using baseline frailty index predicted motoric cognitive risk syndrome, with higher frailty linked to increased MCR risk in adults aged 45 and older.
Predictive utility was limited to modest performance when using baseline frailty index alone, and findings are restricted to CHARLS participants aged 45 and older.
Evidence
- Peer-reviewedJournal of the Formosan Medical Association2026-08-29
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Truvace Impact Record TRV-2026-0936, v1: “The impact of frailty and its changes on the development of motoric cognitive risk syndrome in middle-aged and older adults.” Truvace, 2026-08-31. /record/TRV-2026-0936 (accessed at citation time). sha256 23e4485cbe6c5f72…
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