aceTargeting GLS and LPIN2 in renal fibroblasts: potential therapeutic targets for kidney stone disease identified by integrated multi-omics analysis
Kidney stones (KS) are a common urological condition, the aetiology of which remains incompletely understood. This study aimed to investigate the key cell types involved in the formation of kidney stones and the molecular mechanisms associated with calcium metabolism. Single-cell and bulk RNA-seq datasets related to kidney stones were downloaded from the GEO database. Single-cell analysis was performed to explore the heterogeneity of kidney stones and identify differentially expressed genes (DEGs). Candidate gen…
Integrated single-cell analysis and three machine learning algorithms identified GLS and LPIN2 as upregulated key genes in kidney stones that promote fibroblast-to-myofibroblast transition, ROS production, calcium deposition and osteogenic-like differentiation, supporting a risk prediction nomogram and drug prediction.
Evidence
- Peer-reviewedUrolithiasis2026-08-22
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Truvace Impact Record TRV-2026-0867, v1: “Targeting GLS and LPIN2 in renal fibroblasts: potential therapeutic targets for kidney stone disease identified by integrated multi-omics analysis.” Truvace, 2026-08-24. /record/TRV-2026-0867 (accessed at citation time). sha256 4f202974420f3f4a…
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