Multi-omics strategies for biomarker discovery and application in personalized oncology
Multi-omics strategies, integrating genomics, transcriptomics, proteomics, and metabolomics, have revolutionized biomarker discovery and enabled novel applications in personalized oncology. Despite rapid technological developments, a comprehensive synthesis addressing integration strategies, analytical workflows, and translational applications has been lacking. This review presents a comprehensive framework of multi-omics integration, encompassing workflows, analytical techniques, and computational tools for bot…
Integration of genomics, transcriptomics, proteomics and metabolomics using machine learning and deep learning has produced biomarker panels that support cancer diagnosis, prognosis and therapeutic decision-making.
Multi-omics biomarker approaches face persistent challenges in data heterogeneity, reproducibility, and clinical validation across diverse patient populations.
Clinical translation remains limited by data heterogeneity, reproducibility issues, and lack of validation across diverse patient populations.
Evidence
- Peer-reviewedMolecular Biomedicine2025-11-21
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Truvace Impact Record TRV-2026-0831, v1: “Multi-omics strategies for biomarker discovery and application in personalized oncology.” Truvace, 2026-08-18. /record/TRV-2026-0831 (accessed at citation time). sha256 023dcc136a041e0a…
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