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TRV-2026-0755Certified recordPeer-reviewed

Additional sectioning and AI-assisted diagnosis reveal underdiagnosis of serous (pre)malignancies in fallopian tube specimen from BRCA1/2 carriers

Aim Germline BRCA1/2 pathogenic variant carriers are at increased risk for high-grade serous carcinoma (HGSC) and are therefore advised to have a risk-reducing salpingo-oophorectomy (RRSO) around the age of 40. A risk of 0.9% to develop peritoneal HGSC (pHGSC) remains, which increases up to 27.5% when serous tubal intraepithelial carcinoma (STIC) is detected at RRSO. The relationship between the detection of STIC and the occurrence of pHGSC is still poorly understood. Here, we investigated the role of tissue sam…

Health · The Trace — both readings · certified 2026-08-14 · v1 · article view · machine-readable

Current reading — gain

Additional sectioning at 150 μm intervals with deep learning support detected isolated STIC or HGSC in BRCA1/2 carriers whose initial RRSO pathology was negative but who later developed peritoneal HGSC.

Current reading — problem

Standard initial pathology of RRSO specimens missed serous (pre)malignancies in BRCA1/2 carriers, leaving occult STIC or HGSC undetected in patients who subsequently developed peritoneal HGSC.

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Truvace Impact Record TRV-2026-0755, v1: “Additional sectioning and AI-assisted diagnosis reveal underdiagnosis of serous (pre)malignancies in fallopian tube specimen from BRCA1/2 carriers.” Truvace, 2026-08-14. /record/TRV-2026-0755 (accessed at citation time). sha256 d1ca7a058a8c2d54…

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